WebModern theranostic medicine uses sophisticated biochemistry to treat cancers such as: Neuroendocrine cancer. Investigations with additional alpha-particle emitting theranostics, including with generator-produced [213Bi]PSMA-617 and [212Pb]PSMA-617 (57, 73), are also being evaluated, which may alleviate sourcing issues regarding 225Ac. Bookshelf Federal government websites often end in .gov or .mil. Sci Rep. 2022 Jul 29;12(1):13034. doi: 10.1038/s41598-022-17460-0. (2019) 19:23. doi: 10.1186/s40644-019-0211-y, 50. Clin Cancer Res. Accessibility doi: 10.1146/annurev-med-051517-011947, 12. The present review helps provide context and an overview of the new options and methods leveraged to detect, characterize, and combat disease in this evolving clinical landscape. Theranostics in men with metastatic castration-resistant prostate cancer (mCRPC) has been developed to target bone and the tumor itself. (2019) 9:20. doi: 10.1186/s13550-019-0488-7, 94. Pathol Oncol Res. PMC Prostate cancer (PCa) is the most common malignancy in men. official website and that any information you provide is encrypted (2018) 59:153843. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Disclaimer. Intra-individual comparison of 68Ga-PSMA-11 and 18F-DCFPyL normal-organ biodistribution. The impact of PSMA-based PET/computed tomography imaging on treatment strategies and prognosis is promising, but still not unquestionably clear. Gafita A, et al. The implementation of an expanding array of nuclear medicine approaches to accurately characterize disease status enabling personalized patient management for prostate cancer patients is beginning to be realized. Standard treatment is insufficient for some patients with high-risk localized prostate cancer, and the emerging field of theranostics provides a potential opportunity to improve outcomes, Karen Elizabeth Hoffman, MD, MHSc, MPH, explained in a presentation at the SUO 23rd Annual Meeting. Thus, even in CRPC disease, the AR pathway thus remains an appropriate therapeutic and imaging target. sharing sensitive information, make sure youre on a federal We are not engaged in rendering medical advice or professional services and we are not a substitute for professional care. McCarthy M, Francis R, Tang C, Watts J, Campbell A. WebTheranostics enables us to combine a fast and accurate cancer diagnosis with precisely targeted therapy. German multicenter study investigating 177Lu-PSMA-617 radioligand therapy in advanced prostate cancer patients. EJNMMI Phys. doi: 10.1007/s12149-019-01404-2, 52. Rahbar K, Boegemann M, Yordanova A, Eveslage M, Schfers M, Essler M, et al. Small molecules can have exquisite targeting sensitivity and specificity, and they allow a much more rapid turnaround from agent injection to imaging (minutes to hours) than do antibodies (days). Bostwick DG, Pacelli A, Blute M, Roche P, Murphy GP. Disclaimer. Lead-212 Theranostics Present Tantalizing Opportunity to Improve Radiopharmaceutical Access | Precision Oncology News Niaz MJ, Batra JS, Walsh RD, Ramirez-Fort MK, Vallabhajosula S, Jhanwar YS, et al. 2023 Feb 3;13(3):564. doi: 10.3390/diagnostics13030564. Bookshelf Front. Unable to load your collection due to an error, Unable to load your delegates due to an error. Thus, imaging the expression levels of AR is a viable strategy to measure receptor density and the pharmacological response to these anti-androgen therapies (22, 23) (Figures 2BD). Leibowitz R, Davidson T, Gadot M, Aharon M, Malki A, Levartovsky M, Oedegaard C, Saad A, Sandler I, Ben-Haim S, Domachevsky L, Berger R. Oncologist. J Nucl Med. It also enables Dr. Fanti emphasized that it is important that we use such tools as decision aids, not treatment selection tools (i.e. Caregiving Perfection was Never the Goal Then What Is? The .gov means its official. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Prospective study of the radiolabeled GRPR antagonist BAY86-7548 for positron emission tomography/computed tomography imaging of newly diagnosed prostate cancer. . 8600 Rockville Pike 93. (2017) 44:166370. Eur J Nucl Med Mol Imaging. However, the eventual progression on novel antiandrogens, Radium-223, and chemotherapies leave considerable room for improvement. doi: 10.1021/bc200279b. sharing sensitive information, make sure youre on a federal WebFigure 2. Larimer BM, Dubois F, Bloch E, Nesti S, Placzek M, Zadra G, et al. Prostate specific membrane antigen expression in prostatic intraepithelial neoplasia and adenocarcinoma: a study of 184 cases. 2020 Oct 20;11:591667. doi: 10.3389/fgene.2020.591667. Teo MY, Rathkopf DE, Kantoff P. Treatment of advanced prostate cancer. doi: 10.1007/s12253-008-9104-2, 29. However, the role of molecular imaging has not been well established yet. At Peter Mac in Melbourne, we are offering lutetium PSMA treatment to men via clinical trials, and we may have a clinical trial suited to you. Epub 2017 Jul 13. van der Gaag S, Bartelink IH, Vis AN, Burchell GL, Oprea-Lager DE, Hendrikse H. Biomedicines. Prostate-specific membrane antigen (PSMA), a protein, is highly expressed on prostate cancer cells. Cancer J. Prostate-specific membrane antigen (PSMA) is a promising theranostic target for the treatment of prostate cancers. Epub 2019 Mar 7. Copyright 2020 Abou, Benabdallah, Jiang, Peng, Zhang, Villmer, Longtine and Thorek. In patients with biochemical relapse, PET/CT positivity is directly associated with prostate-specific antigen (PSA) increase and amounts to roughly 50% when PSA is raised to 0.5 ng/ml and to 90% above 1 ng/ml. MDV3100 treatment, a second-generation orally bioavailable anti-androgen, was tested in men with castrate-resistant prostate cancer. Buteau JP, et al. Would you like email updates of new search results? Lancet Oncol 2021. and transmitted securely. Prostate-specific membrane antigen (PSMA) has been the subject of numerous studies within the last 3 decades. Kusumi T, Koie T, Tanaka M, Matsumoto K, Sato F, Kusumi A, et al. Evaluation of PSMA expression changes on PET/CT before and after initiation of novel antiandrogen drugs (enzalutamide or abiraterone) in metastatic castration-resistant prostate cancer patients. J Nucl Med. doi: 10.1007/978-1-4612-4502-5_4, 79. doi: 10.1007/s00109-015-1329-4, 90. doi: 10.2967/jnumed.118.219592, 56. Oncotarget. This review Hell J Nucl Med. Eur Urol Oncol. Farolfi A, Fendler W, Iravani A, Haberkorn U, Hicks R, Herrmann K, Walz J, Fanti S. Eur Urol Oncol. Radium 223 (Xofigo), landing in bone, specifically at the bone metastases, emits alpha particles that will kill cancer cells. (A) Adenocarcinoma arising in the prostate gland is the second most common cancer in males, and can be cured with local intervention if detected when still localized to the organ. A special focus of this review is on PSMA PET-guided management of patients receiving PSMA-targeted radioligand therapy. Disclaimer. alpha particle; peptide; prostate cancer; radionuclide; radiotherapy. doi: 10.1007/s10555-013-9471-3, 8. The .gov means its official. This article does not contain any studies with animals performed by any of the authors. 1345-1347. *Correspondence: Diane Abou, dabou1@wustl.edu; Daniel L. J. Thorek, thorek.lab@wustl.edu, Theranostic Imaging in Cancer Precision Medicine, View all
2020 Mar;23(1):38-52. doi: 10.1038/s41391-019-0174-x. Would you like email updates of new search results? Sathekge M, Bruchertseifer F, Knoesen O, Reyneke F, Lawal I, Lengana T, et al. 2016 Nov;46(6):522-535. doi: 10.1053/j.semnuclmed.2016.07.006. doi: 10.1097/PPO.0b013e31827f123e, 5. We then use Lutetium 177 PSMA to treat the cancer. doi: 10.1053/ctrv.2000.0210, 89. J Urol. Furthermore, patients with a lower PSMA-PET whole body tumor volume (prognostic variable) have superior survival outcomes compared to those with higher volume of PSMA-positive disease: Based on results from the VISION trial, Gafita et al. doi: 10.1097/01.ju.0000091655.77601.0c. Accessibility Urology. sharing sensitive information, make sure youre on a federal (2013) 19:6670. Abou DS, Rittenbach A, Tomlinson RE, Finley PA, Tsui B, Simons BW, et al. In 2019 there were ~175,000 new cases of PC with >30,000 deaths, yielding enormous personal, societal, and economic costs (1). This site needs JavaScript to work properly. Current commonly accepted eligibility criteria for 177Lu-PSMA therapy, include: 1. (2010) 375:143746. Lutetium-177-conjugated PSMA-617 or PSMA-I&T (Lu-PSMA) has shown promising results in multicenter retrospective and monocenter prospective trials. doi: 10.1200/JCO.2005.05.160, 62. J Nucl Med. Even after applying exclusion criteria (e.g., liver metastasis <2.5 cm) based on CT/MRI findings, a significant proportion of patients in the experimental arm did not derive a clinical benefit from 177Lu-PSMA-617.2. Wynant GE, Murphy GP, Horoszewicz JS, Neal CE, Collier BD, Mitchell E, et al. Curr Med Chem. Contemporary prostate cancer states and systemic treatments. These approvals result from significant survival benefits for patients at multiple lines of treatment. 2017 Nov;56(11):1440-1444. doi: 10.1007/s00120-017-0510-5. Pfister J, Bata R, Hubmann I, Hrmann AA, Gsaller F, Haas H, Decristoforo C. J Fungi (Basel). In prostate cancer, theranostics involves using the same radioisotope to identify or diagnose where the prostate cancer is located and also to use it to treat the Siegel RL, Miller KD, Jemal A. National Library of Medicine Immunoscintigraphy with indium-111-capromab pendetide: evaluation before definitive therapy in patients with prostate cancer. WebRapid developments in imaging and treatment with radiopharmaceuticals targeting prostate cancer pose issues for the development of guidelines for their appropriate use. PSMA Theranostics: Current Landscape and Future Outlook. Keywords: WebTheranostics in men with metastatic castration-resistant prostate cancer (mCRPC) has been developed to target bone and the tumor itself. No use, distribution or reproduction is permitted which does not comply with these terms. Diagnostic PSMA Antibody targeting vectors with high affinity for PSMA have also been labeled with positron, beta-particle and alpha-particle emitting radionuclides. Characterization of bone metastases from rapid autopsies of prostate cancer patients. Filippi L, Chiaravalloti A, Schillaci O, Cianni R, Bagni O. 2020 Jun;61(6):857-865. doi: 10.2967/jnumed.119.236414. [18F]-FDHT, which annotates the AR, the central molecular driver of prostate cancer development and progression, is an effective imaging tool to evaluate pharmacodynamic features of candidate therapies. Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer. TESTICULAR, PENILE & RARE GU MALIGNANCIES, The RALU Study: Treatment Considerations in the First Line Setting of mCRPC, EAU 2023 Upper Tract Urothelial Carcinoma, 2023 European Association of Urology (EAU) 38th annual congress held in Milan, Italy between March 10th and 13th, 2023, Use nomograms as an outcomes predictor, not a treatment selector, Treat what you see (basic principle of theranostics). (2019) 2:16673. 89Zr-huJ591 immuno-PET imaging in patients with advanced metastatic prostate cancer. Violet J, Sandhu S, Iravani A, Ferdinandus J, Thang SP, Kong G, Kumar AR, Akhurst T, Pattison DA, Beaulieu A, Mooi J, Tran B, Guo C, Kalff V, Murphy DG, Jackson P, Eu P, Scalzo M, Williams S, Hicks RJ, Hofman MS. J Nucl Med. Front Oncol. (2012) 14:4237. For more details on 177Lu-PSMA treatment,this is an excellent recent review from the European Society of Radiology. (2018) 45:129. Prostate specific membrane antigen (PSMA) ligands for diagnosis and therapy of prostate cancer. doi: 10.1007/s00259-005-1764-5. Stephens A, Loid I WC, Beheshti M, Jambor I, Kemppainen J, Bostrom P, et al. (C) Representative baseline and treatment scans showing marked decrease in radio-androgen uptake in skeletal metastases. 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