An official website of the United States government. Our areas of scientific interest include: To viewa comprehensive list of our upcoming and previous research seminars visitour seminar page. Radiotherapy means the use of radiation, usually x-rays, to treatcancer. Share on Twitter. Please enable it to take advantage of the complete set of features! Previously published experiences using cone-beam computed tomog Citation Impact 4.309 -2-year Impact Factor(2021) 4.269 -5-year Impact Factor(2021) 1.244 -Source Normalized Impactper Paper (SNIP) 1.093- SCImago Journal Rank (SJR), Speed 31 days to first decision for all manuscripts (Median) 42 days to first decision for reviewed manuscripts only (Median), Usage 1,779,104Downloads (2021) 991 Altmetric mentions (2021). Int J Surg. 10 National Center for Tumor diseases (NCT), Heidelberg, Germany. It is also sometimes possible to have more than one treatment per day. 2021;4(2):200-207. Radiation dermatitis is a major concern in intensity modulated proton therapy (IMPT) for head and neck cancer (HNC) despite its demonstrated superiority over contemporary photon radiotherapy. WebResearchers from Columbias Department of Radiation Oncology, the HICCC, and CRR have established a team dedicated to FLASH radiotherapy research at Unable to load your collection due to an error, Unable to load your delegates due to an error. By using our site, you acknowledge that you have read and understand our Privacy Policy Integrating magnetic resonance (MR) into radiotherapy planning has several advantages. Cancer Research UK is a registered charity in England and Wales (1089464), Scotland (SC041666), the Isle of Man (1103) and Jersey (247). You might have radiotherapy from inside the body, called internal radiotherapy. Epub 2018 Jul 4. Manage cookies/Do not sell my data we use in the preference centre. This can cause side effects in thetreatment area. But you might have electrons or more rarely protons. Many cancer patients receive radiotherapy as part of their treatment. Detecting the Research Trends and Hot Spots in External Irradiation Therapy for Rectal Cancer. Contact: ThaoEichhorn National Cancer Research Institute. Several competitive schemes are available for three-four year PhD studentships(MRC, YCR, CRUK, NIHR etc). Apart from any fair dealing for the purpose of private study or research, no Elsevier LTD, 2012, Practical Radiotherapy Planning Call freephone 9 to 5 Monday to Friday or email us, Find out more about internal or external radiotherapy, Find out more about the side effects of radiotherapy, Find out about having radiotherapy with a pacemaker, any other treatment you've had, are having, or is planned for you. 2021 Dec 1;13(1):212. doi: 10.1186/s13148-021-01199-y. The present analysis evaluated the secondary endpoints of health-related qualit Mesorectal motion (MM) is a source of uncertainty during neoadjuvant chemoradiotherapy (nCRT) delivery for locally advanced rectal cancer (LARC). sharing sensitive information, make sure youre on a federal Rapid and relentless technological advances in an ever-more globalized world have shaped the field of radiation oncology in which we practise today. P Hoskin and C Coyle This analysis revealed that, over the years, radiotherapy research output has declined relative to alternative cancer therapies, representing 64% in 1970 it decreased to 31% in 2019. Phys Imaging Radiat Oncol. WebRadiation Oncology encompasses all aspects of research that impacts on the treatment of cancer using radiation. 2022 Nov 9;24:129-135. doi: 10.1016/j.phro.2022.11.002. Priorities for cancer research in low- and middle-income countries: a global perspective. To do so, the data from >350,000 scientific publications pertaining to a yearly search of the PubMed database with the keywords cancer radiotherapy was analysed. Our dedicated access representatives canhelp you make an appointment today. Also, the pace of research has significantly accelerated with, in the last 15 years, a doubling in the number of articles published by the 10% most productive researchers. Bookshelf Using their proven isolation method, researchers in the Molecular Radiotherapy Research Labare working in collaboration with investigators Matt OHara and his team at the Pacific Northwest National Laboratory to automate the process. An image of a cartoon face with a neutral expression. Acta Orthop Traumatol Turc. Death from prostate cancer occurred in 3.1% of the active-monitoring group, 2.2% in the surgery group, and 2.9% in the radiation group, differences considered statistically insignificant. WebRadiotherapy Outcomes Explorer (ROE) is useful in exploring the clinical impact of scaling dose on Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP) in radiotherapy. HHS Vulnerability Disclosure, Help To circumvent this problem, Dr. Wilbur and his research group have developed a new method for attaching At-211 to targeting agents. This team has made improvements inthe technology to automate the isolation process and, in time, plans to make itavailable to advance At-211 research efforts around the world. The Most Popular Radiotherapy Topics in 2019 Six of the top 20 radiotherapy stories in 2019 involved proton therapy. Want to find more information about our research or radiotherapy? FOIA We know that it is common to struggle with your mental health when you have cancer or care for someone with cancer. Aggarwal A, Lewison G, Idir S, Peters M, Aldige C, Boerckel W, Boyle P, Trimble EL, Roe P, Sethi T, Fox J, Sullivan R. J Thorac Oncol. Radiother Oncol. The trial tackles the disease on two fronts by targeting both the prostate and pelvic area with radiotherapy, and by boosting treatment to the tumour itself. 2022 6 Department of Radiology, Johns Hopkins University, Baltimore, Maryland. The group is a multi-disciplinary community of researchers and patients focused on issues relating to radiotherapy research. and transmitted securely. After production, it is isolated from the bismuth target material by a wet chemistry approach. In addition to cancer applications, early investigations of the use of At-211-labeled antibodies for HCT treatment of patients with HIV are being investigated through collaborations with investigators (Dr. Brenda Sandmaier, Dr. Ann Woolfrey, and others) at the Fred Hutch. Professor Uwe Oelfke, based in Sutton, originally trained in nuclear physics but is now researching ways to make radiotherapy more precise. Our scientists are working to make it even more effective and to reduce Your doctor will tell you how many treatments youll have. Efforts to produce radioisotopes are being conducted through a partnership with the U.S. Department of Energy, which is providing funding for facilities-upgrades and methods-development, and will distribute some of the isotopes to meet the needs of researchers throughout theUnited States. WebTreat BCC and SCC with Low-Energy Radiation Therapy. A company limited by Automation has become an integral part of the production of isotopes used in clinical practice, as it provides a method to obtain consistent quantities and quality while minimizing radiation dose to operators. The group has identified He worked as a lead technician in the trace metals laboratory at Weyerhaeuser Corporation (Federal Way, WA) from 1989 to 1991. NCRI CTRad's Top 10 achievements, published in 2019 to mark the group's 10th anniversary, highlights the significant and lasting influence the group has had on the U.K.'s cancer research landscape, and the group has continued to thrive despite the very significant challenges of the global pandemic.". Regional lymph node irradiation in younger trials seems to provide superior target coverage as well as a reduction in long-term toxicity resulting in a small benefit in the overall survival rate. and Terms of Use. Berger T, Noble DJ, Yang Z, Shelley LEA, McMullan T, Bates A, Thomas S, Carruthers LJ, Beckett G, Duffton A, Paterson C, Jena R, McLaren DB, Burnet NG, Nailon WH. Epub 2016 Feb 10. Currently, there is very little published clinical data, especially in the context of curative multimodal therapy with image-guided, Methylprednisolone is recommended as the front-line therapy for radiation-induced brain necrosis (RN) after radiotherapy for nasopharyngeal carcinoma. Dr. Wilbur and his research groupsfocus is onpre-clinical radiochemical and radiopharmaceutical studies, but personnel in the radiochemistry lab collaborateclosely with research partners to translate the workinto clinical studies. The most active reagent-development research are in the areas of hematopoietic cell transplantation and for therapy of lymphoma, leukemia, multiple myeloma and prostate cancers. These molecular radiotherapy agents are designed to selectively target radiation to blood and cancer cells so that one day they can diminish or eliminate the need for more toxic treatments, such as total body irradiation. It is a unifying voice for radiotherapy research in the U.K. and the only national multidisciplinary research group globally that drives bench to bedside research in radiotherapy. However, the time it takes to target some distant cancer sites has suggested that new targeting agents with faster targeting properties must be developed. Find out what these side effects are and how they affect you during and after treatment. Each section has detailed information about symptoms, diagnosis, treatment, research and coping with cancer. According to the team, only a handful of machines configured for FLASH radiotherapy research exist in the world, including at centers at Stanford University and Lund University in Sweden. Donald Hamlin has been in the Molecular Radiotherapy Research Lab since 1991. MeSH WebRadiation therapy (also called radiotherapy) is a cancer treatment that uses high doses of radiation to kill cancer cells and shrink tumors. The .gov means its official. NCRI CTRad strategic priorities: www.ncri.org.uk/wp-content/upl gic-priorities-2.pdf. Berger T, Noble DJ, Shelley LEA, Hopkins KI, McLaren DB, Burnet NG, Nailon WH. Drs. Because of the short half-life of At-211 (~7 hours), it must be made immediately before its use. Provided by Use this form if you have come across a typo, inaccuracy or would like to send an edit request for the content on this page. Regional lymph node irradiation in younger trials seems to provide superior target coverage as well as a reduction in long-term toxicity resulting in a small benefit in the overall survival rate. The https:// ensures that you are connecting to the With FLASH, we would be capable of giving higher doses of radiation to patients, which has the potential to be more effective treatment that is less toxic and given much quicker. 206.598.4090. Hodder Arnold, 2009, Radiotherapy in Practice - Brachytherapy The new The feasibility of FLASHRT widely used in clinical practice, and whether it could be combined with immune checkpoint inhibitors to guide therapy, are reviewed. The United States was responsible for 32.3% of these outputs, followed by Japan (8.0%) and Germany (7.7%). The site is secure. Attaching radioisotopes to biological agents that selectively target cancer cells. Your feedback is important to us. Radiation therapy is the cornerstone of treatment for adult-type diffuse gliomas, but recurrences are inevitable. When deciding on your course of treatment your doctor takes into account: Radiotherapy with the aim of curing cancer usually lasts between 1 to 7 weeks. This includes two video inetrviews Nearly half of all publications related to preparation and delivery of radiation therapy, combined-modality regimens, and dose fractionation studies. Together with our colleagues in the Department of Radiation Oncology, collaborative efforts will define the mechanistic basis for the radioactive effects of FLASH on normal tissue, the eradication of tumors, and advance the technology to a clinical setting for the treatment of cancer patients., We are all very interested in this new technology, and its a very exciting idea, says Dr. Brenner. 2020 Nov;150:105191. doi: 10.1016/j.earlhumdev.2020.105191. Our scientists are working to make it even more effective and to reduce its side effects. Radiat Oncol. Radiation therapy has a pivotal role in the treatment of cancer. Another area of interest that the Columbia team is examining is the role oxygen depletion plays in FLASHs ability to kill targeted tumors while sparing adverse effects on surrounding healthy tissue. An official website of the United States government. Letters. Worldwide productivity in the hand and wrist literature: A bibliometric analysis of four highly cited subspecialty journals. Self-funded students: International or domestic self-funded or scholarship/fellowship PhD students are welcome to apply for a place in the laboratory or clinic. 2022 Share on Facebook. Dr. Wilbur's team is working with Fred Hutch investigators to determine if the use of highly potent radiation from At-211-labeled antibodies can replace TBI, resulting in a less toxic treatment. The .gov means its official. Art of publication: A beginner's guide to understanding the non-linear dynamics between research and publication. Additional studies are being conducted in hepatocellular carcinoma. Read more about what it is and how you have it, including treatment with radioactive implants and radioactive liquid. J Med Imaging Radiat Oncol. Front Cell Dev Biol. and transmitted securely. WebThe Radiation Research Society educational resource center is a benefit to the scientific community, featuring an extensive content that will capture your interest, regardless of The emerging technique, called FLASH radiotherapy, has the promise to drastically shorten radiation treatment for patients with cancer. Conclusion: Radiotherapy is an effective tool for palliative treatment of BM and LC. After successful preclinical investigations, the research collaboration is now preparing for clinical investigations using At-211-labeled antibodies in HCT. WebRadiotherapy (WBRT and involved-field irradiation of bulky spinal lesions) and chemotherapy (systemically or intrathecally applied methotrexate, thiotepa and cytarabine) are both effective and may prolong survival from several weeks to 4-6 months. Hassan S, Oar A, Ward I, Koh ES, Shakespeare TP, Yap ML. Greater support for radiation therapy research in low- and middle-income countries is required, including international collaboration. Radiotherapy means the use of radiation, usually x-rays, to treat cancer. Astatine-211 is not currently available from commercial sources, so it must be prepared on-site for pre-clinical and clinical investigations. Find out about cancer treatment with radiotherapy,including external radiotherapy, internal radiotherapy, side effects, radiotherapy for symptomsand follow up after treatment. This site uses cookies to assist with navigation, analyse your use of our services, collect data for ads personalisation and provide content from third parties. Most types of radiotherapy use photons. It publishes findings in molecular and cellular radiation biology, radiation physics, radiation technology, and clinical oncology. Predicting radiotherapy-induced xerostomia in head and neck cancer patients using day-to-day kinetics of radiomics features. Researchers in the lab, working with teams of investigators at UWand Fred Hutch, are developing new waysof treating cancer. Bethesda, MD 20894, Web Policies Ionizing radiations induce shared epigenomic signatures unraveling adaptive mechanisms of cancerous cell lines with or without methionine dependency. Epub 2021 May 10. Many cancer patients receive radiotherapy as part of their treatment. The life-saving research we do wouldnt be possible without your support. 7 Voximetry Inc. 8 Hospital of the University of Pennsylvania. Due to the Job specializations: Research/Development. Accessibility The Learning from these trends is crucial for the Wolters Kluwer Health, 2019, External Beam Therapy (2nd edition) Oxford University Press, 2012, Cancer and its Management (7th edition) The UW Medical Cyclotron Facility is one of only a few cyclotrons in the U.S. that have an alpha beam capability. WebASTRO-Novocure Radiation Oncology Research Training Fellowship Providing an opportunity to spend a year in Israel, this fellowship is designed to provide training and in-depth understanding on Tumor Treating Fields (TTFields) dosimetry and treatment planning through active participation in R&D projects. You can unsubscribe at any time and we'll never share your details to third parties. In this article we present an analysis of trends in radiation oncology research over the last half a century. This research effort involves developing methods for: The Molecular Radiotherapy Research Labcurrently has multiple ongoing pre-clinical studies with investigators at UW and Fred Hutch. Copyright 2021 Elsevier B.V. All rights reserved. This special issue aims to highlight the state-of-the-art in modeling radiotherapy response in animal models, and to demonstrate the broad range of experimental approaches currently being explored. Additionally, radiotherapy research output is extremely unequally distributed in the world, with Africa and South America contributing to 3% of radiotherapy articles in 2019 while representing 23% of the world's population. Oxford University Press, 2011. Despite intensive basic scientific, translational, and clinical efforts in the last decades, glioblastoma remains a devastating disease with a highly dismal prognosis. Gender-related and geographic trends in interactions between radiotherapy professionals on Twitter. official website and that any information you provide is encrypted You might have it by itself or with other treatments, such as chemotherapy or surgery. Treasure Island (FL): StatPearls Publishing; 2022 Jan. International students must meet requirements for written and spoken English set out by the Graduate School. Examples of theranostic radioisotopes that have been prepared are rhenium-186 and tin-117m. 9 Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany. Siblini Y, Chry C, Rouyer P, Raso J, Julien A, Hergalant S, Franois A, Bezdetnaya L, Vogin G, Guant JL, Oussalah A. Clin Epigenetics. More information: An image of a cartoon face that is very unhappy. The objective of this study is to r High-grade gliomas are the most common intracranial malignancies, and their current prognosis remains poor despite standard aggressive therapy. In a long-term collaboration with Dr. Robert Vessella, retired professor in UW's Department of Urology, encouraging results have been obtained. Box 356043
Bench fees are required if you are self-funded. We have also recently secured3.5 million from Cancer Research UK to fund advances in radiotherapy research as a RadNet Leeds centre, focusing on the use of artificial intelligence with imaging technology. Early Hum Dev. Anussara Prayongrat, Natchalee Srimaneekarn, Kanokporn Thonglert, Chonlakiet Khorprasert, Napapat Amornwichet, Petch Alisanant, Hiroki Shirato, Keiji Kobashi and Sira Sriswasdi, Leon Emanuel Schnller, Daniel Piehlmaier, Peter Weber, Nikko Brix, Daniel Felix Fleischmann, Alexander Edward Nieto, Martin Selmansberger, Theresa Heider, Julia Hess, Maximilian Niyazi, Claus Belka, Kirsten Lauber, Kristian Unger and Michael Orth, Simiao Qiao, Yuying Hao, Linbo Cai, Xiaotong Duan, Lijuan Wang, Aidong Zhou and Xiaoxia Zhu, Shaonan Fan, Qi Zhang, Jingyao Chen, Gang Chen, Jiangyi Zhu, Tingting Li, Han Xiao, Shisuo Du, Zhaochong Zeng and Jian He, Jian-Xu Li, Rui-Jun Zhang, Mo-Qin Qiu, Liu-Ying Yan, Mei-Ling He, Mei-Ying Long, Jian-Hong Zhong, Hai-Yan Lu, Hong-Mei Zhou, Bang-De Xiang and Shi-Xiong Liang, Friedemann Schad, Diana Steinmann, Shiao Li Oei, Anja Thronicke and Christian Grah, Shanshan Song, Dongmei Han, Ning Zhang, Zhuang Mao, Xin Guo and Guanghui Cheng, Masanori Hirata, Kazuaki Yasui, Naofumi Oota, Hirofumi Ogawa, Tsuyoshi Onoe, Sayo Maki, Yusuke Ito, Kenji Hayashi, Hirofumi Asakura, Shigeyuki Murayama, Koichi Mitsuya, Shoichi Deguchi, Katsumasa Nakamura, Nakamasa Hayashi, Tetsuo Nishimura and Hideyuki Harada, Hendrik Dapper, Christian Diehl, Carolin Knebel, Carolin Mogler, Kai Borm, Sophie Dobiasch, Stephanie E. Combs and Jan C. Peeken, Xiaohuang Zhuo, Huiying Zhao, Meiwei Chen, Youqing Mu, Yi Li, Jinhua Cai, Honghong Li, Yongteng Xu and Yamei Tang, Paulina M. Gutkin, Elizabeth Gore, John Charlson, John C. Neilson, Candice Johnstone, David M. King, Donald A. Hackbarth, Adam Wooldridge, Rajeev Mannem and Meena Bedi, Lianshuang Xia, Xiaoxu Li, Jie Zhu, Zhaisong Gao, Ju Zhang, Guangjie Yang and Zhenguang Wang, Yusaku Miyata, Etsuyo Ogo, Toshi Abe, Hideki Hirata, Naotake Tsuda, Kimio Ushijima, Akihiko Kawahara, Jun Akiba, Hitoshi Obara and Tatsuyuki Kakuma, Makoto Ito, Yasuo Yoshioka, Yuuki Takase, Junji Suzuki, Hironori Takahashi, Yoshitaka Minami, Ami Sakuragi, Yukihiko Oshima, Takahito Okuda and Kojiro Suzuki, Masahide Matsuda, Masashi Mizumoto, Hidehiro Kohzuki, Narushi Sugii, Hideyuki Sakurai and Eiichi Ishikawa, Jonathan B. Biological target volume based on fluorine-18-fluorode-oxyglucose positron emission tomography/computed tomography imaging: a spurious proposition? Equity should know no borders: The role of Australasian radiation oncologists in supporting radiation oncology services in low- and middle-income countries in the Asia-Pacific. Listing for: Florida Cancer Specialists, P.L. Ming-Kuan Chyan has been in Dr. Wilbur's research group since 1998. At low doses, radiation is used in x-rays The Profile of Non-Communicable Disease (NCD) research in the Middle East and North Africa (MENA) region: Analyzing the NCD burden, research outputs and international research collaboration. WebRadiotherapy is one of the most efficacious, and cost-effective, treatments for cancer and is a component of care in around 40 per cent of all cancer patients cured of their disease. WebInstitute for Applied Medical Research, UNSW, Liverpool, Australia; jThe Netherlands Cancer Registry/Netherlands Comprehensive Cancer Organisation, radiotherapy is a key parameter for planning the resources needed in a specic country in the framework of a cancer control programme. High-dose proton beam therapy (PBT) uses excellent dose concentricity based on the unique characteristic termed the Bragg peak. Death from prostate cancer occurred in 3.1% of the active-monitoring group, 2.2% in the surgery group and 2.9% in the radiation group differences considered statistically insignificant. An important breakthrough in the development of a new and highly accurate radiotherapy treatment for cancer has been achieved. FLASH radiotherapy is the fast delivery of ultra-high dose radiation a thousand times quicker than conventional radiotherapy. A study in the New England Journal of Medicine showed most men diagnosed with localized prostate cancer can actively monitor the disease instead of jumping to surgery or radiation. The new treatment, called FLASH RT, is as effective as current techniques but could also prevent unnecessary damage to healthy tissue and considerably shorten the time that patients spend in hospital. It is therefore important to understand, from a public policy perspective, the evolution of global radiation therapy research, to identify strengths, weaknesses, and opportunities. WebThis research effort involves developing methods for: Obtaining rare radioisotopes, Attaching radioisotopes to biological agents that selectively target cancer cells, He is studying how these treatments work together in the lab, and hopes these insights could lead to new combination treatments being tested in clinical trials for various different types of cancer. Prostate cancer treatment can wait for most men, Oxford study finds Death from prostate cancer occurred in 3.1% of the active-monitoring group, 2.2% in the surgery group and 2.9% in the radiation group differences considered statistically insignificant. Cancer Research UK - ART NET Advanced Radiotherapy Technologies Network Accelerator Award linking Leeds with four other radiotherapy centres in the UK. A company limited by Soft tissue sarcomas (STS) are a relatively rare group of malignant tumors. Terms and Conditions, But this can vary. Researchersare particularly interested in alpha-emitting radioisotopes, as they hold great promise in molecular radiotherapy of blood-borne and metastatic cancers. In recurrent GBM (rGBM), tumor volume (TV) delineation Stereotactic ablative radiotherapy (SABR) is a validated treatment for early stage lung cancer and pulmonary metastases. External radiotherapy targets radiationat the cancer from a radiotherapy machine. January 18, 2023 Achievement: A group of ORNL researchers and collaborators have been working to develop a pipeline that simulates radiotherapy across different scales, e.g., the individual cellular scale, multicellular/tissue scale, organ scale, and whole-body scale. MeSH WebThe Radiotherapy Research Group. 8600 Rockville Pike The sessions allowed for discussion on the overarching challenges, opportunities and gaps in radiotherapy research and specific issues and areas of unmet need in the field. It can help to talk through any worries you have with your doctor, nurse or radiographer. Most commonly, this calculation has been carried Recent years have seen both a fresh knowledge of cancer and impressive advancements in its treatment. Search our clinical trials database for all cancer trials and studies recruiting in the UK, Questions about cancer? 2006 Feb 28;1:1. doi: 10.1186/1748-717X-1-1. Thus, an automated method for isolation of At-211 from bismuth targets is being developed to make it possible for non-experts to isolate At-211. Meet people like Oliver who have experienced first-hand how our research is making a difference. An important breakthrough in the development of a new and highly accurate radiotherapy treatment for cancer has been achieved. Unable to load your collection due to an error, Unable to load your delegates due to an error. Apart from the implementation of temozolo During the last decades, radiotherapy (RT) for non-small cell lung cancer (NSCLC) with brain metastases (BM) has been developed. Careers. Unauthorized use of these marks is strictly prohibited. HyperArc (H Stereotactic radiation therapy (SRT) is a focal treatment for brain metastases (BMs); thus, 20 to 40% of patients will require salvage treatment after an initial SRT session, either because of local or distant CT ventilation image (CTVI)-guided radiotherapy that selectively avoids irradiating highly-functional lung regions has potential to reduce pulmonary toxicity. Professor Tim Illidge in Manchester is researching how radiotherapy could be combined with immunotherapy, a relatively new type of cancer treatment that harnesses the power of the bodys immune system to fight cancer. The gene of the Epidermal growth factor receptor (EGFR) is one of the most frequently altered genes in glioblastoma (GBM), with deletions of exons 27 (EGFRvIII) being amongst the most common genomic mutations. Approximately 20% of all Bethesda, MD 20894, Web Policies It is estimated that 470,000 patients receive radiotherapy each year in the United States. 2022 Jul;172:149-150. doi: 10.1016/j.radonc.2022.04.002. Wiley Blackwell, 2015, Walter and Miller's Textbook of Radiotherapy: Radiation Physics, Therapy and Oncology (7th edition) He is one of only a few people in the world who have expertise in labeling compounds with At-211. Keywords: Letter to the Editor of Radiotherapy and Oncology regarding the paper entitled "50 years of radiotherapy research: Evolution, trends and lessons for the future" by Berger et al. Previous studies, using mouse lung and brain models, have indicated that by reducing the time interval for delivering a single dose fraction from tens of minutes to a fraction of a second, detrimental effects to normal tissue near the tumor can be reduced, or even avoided altogether, without sacrificing the effectiveness of the radiotherapy in eliminating the cancer.
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