Reproductive toxicity Overexposure may cause reproductive disorder(s) based on tests with laboratory animals. The primary results revealed that the mixture was more effective than using salt alone. 4 0 obj [49] Spanish authorities are prosecuting Asuncin Criado, general manager of Rasfer Internacional, S.A., and await Panamanian citizens, Ren Luciani (former Social Security Director) and Jssica Rodrguez (former Purchase National Director) for their hearings. Nine potential catalysts were investigated for the reaction between PEG and divinyl sulfon and possible death due to respiratory failure. and coma. The micelles had a size distribution of about 10-50 nm and significantly enhanced the cytotoxicity of paclitaxel to LL/2 cells as demonstrated by MTT test (IC=0.21 g/mL for tbFGF conjugated Chol-PEG(2000)-COOH micelles (tbFGF-M-PTX) versus 26.43 g/mL for free paclitaxel, respectively). 2,3-butanediol, often found in the plasma of alcoholics, mistakenly can be identified as ethylene glycol when the analysis is performed by gas chromatography (Jones AW et al. The toothpaste was labeled as "Manufactured in South Africa" and contained misspellings like "isclinically", "SOUTH AFRICA" and "South African Dental Assoxiation". WebEthylene glycol is a synthetic liquid substance that absorbs water. [46], In August 2009, the Supreme Court decided to send the diethylene glycol file to the Public Ministry for an extension. The https:// ensures that you are connecting to the One year and a half after the FDA began to trace the poisonous shipments, an inspector, Ted Sze, finally visited the Tianhong Fine Chemicals Factory in Dalian, northeastern China. These cookies may also be used for advertising purposes by these third parties. After manufacturing a second batch of syrup containing diethylene glycol for Qiquhar Pharmaceutical, no taste-test was performed. Accessibility [BAT (ethanol) divided by 4.6 (if present)], OG = osmolality (measured)* susceptible to autoxidation and therefore should be classified as Further investigation revealed all patients were treated with topical silver sulfadiazine ointment that contained 7g/kg of DEG. stream
Recent development of poly(ethylene glycol)-cholesterol conjugates as drug delivery systems. Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. An elevated serum level of ethylene glycol confirms ethylene glycol poisoning. This being the second incident involving counterfeit glycerine, it prompted the Nigerian National Agency for Food And Drug Administration and Control (NAFDAC) to adopt zero tolerance for counterfeits. They identified Tianhong Fine Chemicals Factory as the manufacturer. Material Safety Data Sheet Ethylene glycol MSDS Section 1: Chemical Product and Company Identification Product Name: Ethylene glycol Catalog Codes: Acute Renal Failure Investigation Team", "Fatal renal failure caused by diethylene glycol in paracetamol elixir: the Bangladesh epidemic", "Identification and Quantification of Diethylene Glycol in Pharmaceuticals Implicated in Poisoning Epidemics: An Historical Laboratory Perspective", "F.D.A. Shortly after, 2-hydroxyethoxyacetaldehyde (C4H8O3) is metabolized by the enzyme aldehyde dehydrogenase (ALDH) into the weak acid 2-hydroxyethoxyacetic acid (HEAA) with chemical formula C4H8O4. Specific target organ toxicity - single exposure (Globally Investigations revealed that all had taken the medicine My Pikin Baby, a teething mixture tainted with diethylene glycol. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. DEG is a widely used solvent. Use of the substance/mixture : For laboratory and manufacturing use only. Patients who have suspected ethylene glycol exposure also should be assessed with serum methanol tests. stream system, liver, reproductive system. Suspecting something wrong with Lisinopril, the medicine was removed from the pharmacies[43] while the U.S. Food and Drug Administration conducted lab analyses, revealing the blood pressure drug was safe; CDC epidemiologists were then invited to participate. cause burning sensation in the chest. Unauthorized use of these marks is strictly prohibited. 4 0 obj %
2010 Aug 17;22(31):3484-94. doi: 10.1002/adma.200904179. [59][60] Although there were no reports of anyone harmed, several people in the eastern US reported experiencing headaches and pain after using the product. Momentan nu am reuit s rspundem solicitrii dumneavoastr. : 57-55-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Synthesis of substances 1.3 Details of the supplier of the safety data sheet Company : Sigma-Aldrich Inc. A Novel Prostate-Specific Membrane-Antigen (PSMA) Targeted Micelle-Encapsulating Wogonin Inhibits Prostate Cancer Cell Proliferation via Inducing Intrinsic Apoptotic Pathway. This event caused the death of five patients.[4][25][26]. Disclaimer. Therefore, the lack of symptoms does not exclude a potentially toxic ingestion (Caravati et al. Subsequently, on 21 October 2022, 99 children were reported dead in Indonesia after ingesting the cough syrups. "R}~Q:~pgg'"l/O:OV~
@zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#w6"egHf_O='i>.xxpo]"a]f&&CY]_[LH=)>~O4v{x?StuS)F;Nf-iLn}tfi7_2O?/U~Q-.S&wy67ON2e5N}s0?zby?~M@tw~`__/ 1. *1 J "6DTpDQ2(C"QDqpIdy~kg} LX Xg` l pBF|l *? Y"1 P\8=W%O4M0J"Y2Vs,[|e92se'9`2&ctI@o|N6 (.sSdl-c(2-y H_/XZ.$&\SM07#1Yr fYym";8980m-m(]v^DW~
emi ]P`/ u}q|^R,g+\Kk)/C_|Rax8t1C^7nfzDpu$/EDL L[B@X! to pulmonary edema. WebProduct name : Propylene Glycol Product Number : P4347 Brand : Sigma-Aldrich CAS-No. Even a small osmolal gap might represent a significant ethylene glycol level. About half were receiving Lisinopril (a blood pressure medicine), and many did not remember clearly if they had been taking other drugs. Communication with the laboratory is critical in poisoning cases for several reasons: All patients with known or suspected ethylene glycol ingestion require the following tests: A blood or serum ethanol level will establish whether ethanol is contributing to the initial CNS symptoms. Calcium oxalate or hippurate crystals in the urine, together with an elevated anion gap or osmolal gap, strongly suggest ethylene glycol poisoning (Albertson 1999). It was assumed that DEG was used as a substitute of propylene glycol, and this incident encouraged the Nigerian government to develop pharmaceutical quality control guidelines. Epub 2010 Mar 20. ?:0FBx$ !i@H[EE1PLV6QP>U(j Nine potential catalysts were investigated for the reaction between PEG and divinyl sulfon [72][73] On 9 June, the police indicted 11 people, including brewery owners and employees, for manslaughter, unintentional bodily harm and food contamination. 2010). %PDF-1.5
Epub 2014 Apr 25. government site. Many studies have shown that renal damage can occur after ethylene glycol ingestion, without deposition of calcium oxalate crystals in the kidney (Hall AH 1992; Vale 1979). 4 0 obj
[2] DEG is a widely used solvent. The WHO issued a medical product alert for four "contaminated" Indian pediatric medicines, manufactured by a firm in Haryana's Sonepat, saying these drugs identified in Gambia had been potentially linked with acute kidney injuries and 70 deaths among children in the west African country. They also arrested 12 people in connection with the incident. The tbFGF could recognize fibroblast growth factor receptors (FGFR) that are highly expressed by a variety of human cancer cells. Yongtai PGDA is a product that combines the excellent properties of CAC, PMA, BCS, and CYC. This strategy can also be applied to other polyhydroxy compounds as crosslinkers, and thus, a library of hydrogels with designed structures and desired properties could be prepared. Wang was caught and Qiquihar was shut down by the authorities. The most commonly used analytic methods for detection and quantification of ethylene glycol use gas chromatography (GC) coupled to flame ionization detection (FID) or mass spectrometric detectors [Juenke et al. [46] In Spain, Rasfer International declared bankruptcy after the lawyer of Medicom filed a lawsuit of $400 million in July 2008. 1993; Hilliard et al. Causes eye irritation. PMC Zhang H, Liu X, Wu F, Qin F, Feng P, Xu T, Li X, Yang L. Int J Mol Sci. %PDF-1.4
8600 Rockville Pike [43], Ending September 2006, the Arnulfo Arias Madrid Hospital at Panama City was getting full with patients with contradictory symptoms. [2][23][33][34], In Bangladesh between 1990 and 1992, 339 children developed kidney failure, and most of them died, after being given paracetamol (acetaminophen) syrup contaminated with diethylene glycol. It is environmentally friendly, low-odor, good leveling, strong solvency, and has higher recombinability in coatings. Polymeric Drug Delivery Systems Bearing Cholesterol Moieties: A Review. Oxa-Michael reaction of M-EG 3 -OH with excess DVS catalyzed with various catalysts, (a) Schematic of PEG gel preparation through the DMAP catalyzed oxa-Michael reaction. : E179-4 CAS No 111-76-2 Synonyms 2-Butoxyethanol; Butyl cellosolve; Butyl glycol Recommended Use extremities. Some wines contained less than 10 parts per million of DEG, a small amount that could not be detected by laboratory analysis in Europe. cause irritation and dermatitis. 2020 Nov 6;12(11):2620. doi: 10.3390/polym12112620. Disclaimer. Ethylene Glycol 107-21-1 Product Summary: Laboratory tests have shown teratogenic and reproductive effects in animals.No data to classify product as an aspiration hazard or to cause specific target organ toxicity through single exposure. Acute Toxicity: LD50 (Dermal) Rabbit 10,626 mg/kg LD50 (Oral) Rat 4,700 mg/kg Irritation: Eyes Unable to load your collection due to an error, Unable to load your delegates due to an error. MSDS Name: Ethylene Glycol Monoethyl Ether Acetate << Timely and accurate measurement of ethylene glycol is vital to establish the correct diagnosis. [43] A New York Times reporter tried to obtain a comment from CNSC Fortune Way at the CPHI Worldwide (the world's largest annual pharmaceutical convention) held in Milan, Italy, during 2007, but their representatives refused to comment. The cough and cold syrups produced by Maiden Pharmaceuticals Limited, Sonepat in India. Mechanical properties of cellularly responsive hydrogels and their experimental determination. Many chronic pain conditions are part of a larger syndrome such as fibromyalgia. Records also revealed that to fool buyers, Wang falsified his license and laboratory analysis reports. [71] On 17 January, the police confirmed the fourth death from symptoms matching DEG poisoning, and DEG contamination had been found in eight brands of beer from the same brewery.
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